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If your levels are normal, I’d think that a week or two shouldn’t be a big deal. I called the pharmacy and got no answers from them either. How does it take in nutrition meanwhile without the homones? Have been off synthroid for 3 weeks; 3 weeks left before screening. You should also make sure you have the medication level checked every 3 months, or whenever your acyclovir and rheumatoid arthritis doctor tells you to come back because you will likely have symptoms if the level is off either way. If someone were to have a total thyroidectomy ( removal of all the thyroid gland), it would take weeks or months for the levels of thyroid hor. A person can go for many years without thyroid hormones. Indeed, people often go undiagnosed for decades despite suffering from hypothyroid symptoms. ETA my daughter was on synthroid for mild hypothyroidism until recently Thyroid removed last year and radioiodine treatment completed. Any longer than 10-12 hours after your last dose, skip it for that day and take it on your normal schedule the next day You can look up the thyroid in wikipedia. I ended up having to go 9 days without it. It is suggested that you just follow the intake dosage and time schedule your personal health care specialist has provided. However, must you happen to miss a Synthroid (thyroxine) dose it’s best to require it as soon as you bear in mind, unless it’s nearly time for an additional dose.. Within a few days to weeks, you can expect symptoms of hypothyroidism, including: Fatigue Brain fog Depression and/or anxiety Constipation Dry skin and hair Hair loss Weight gain. They symptoms are easy enough to identify if your tsh gets too low. Everyone is different, so it's impossible to say how long one could actually live without thyroid hormones. The body can survive for many years without a thyroid gland. Anyways to make a long story short, I had a total thyroidectomy and have been taking synthroid 100mcg (was just dropped down from 112mcg). I'm concerned how serious this could effect me Answer (1 of 11): How long can a body survive without thyroid hormones? You should call the doctor to double check, but if should be fine. Was wondering how long the body can sustain life without hormone therapy. If you are truly hypothyroid, discontinuing your thyroid medication for a longer period of time can have serious consequences. Org and it will tell you all of the systems it helps regulate. Votes: +2 LI Lizard71 4 Aug 2016.